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Nonsteroidal anti-inflammatory drugsincluding indomethacinmay rarely increase the risk for a heart attack or strokeThis effect can happen at any time while taking this drug but is more likely if you take it for a long timeThe risk may be greater if you have heart disease or increased risk for heart diseasefor exampledue to smokingfamily history of heart diseaseor conditions such as high blood pressure or diabetesDo not take this drug right before or after heart bypass surgeryCABG

CholestyramineQuestranand colestipolColestidmay decrease the absorption of indomethacin by binding to indomethacin in the intestine and preventing absorption into the bodyIndomethacin and other NSAIDs may decrease the elimination of lithiumEskalithLithobidby the kidneys andthereforeincrease the blood level of lithiumwhich could lead to lithium toxicity.

Before taking indomethacintell your doctor if you are taking any of the following drugs:

Follow all directions on your prescription labelDo not take indomethacin in larger amounts or for longer than recommendedUse the lowest dose that is effective in treating your condition.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

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